We use high-throughput techniques to understand protein function in homeostasis and disease and to study mechanisms of protein evolution.

In the Pinney Lab, we use high-throughput in vitro and in vivo methods to study the mechanisms of enzyme function, to understand how these functions evolve and adapt, and to understand how these functions contribute to phenotypes in vivo. We study how enzymes evolve and adapt to new environments, with a particular focus on enzyme temperature adaptation, how enzymes are wired in metabolism, and how changes in enzyme function lead to disease. Our research spans the fields of biochemistry, genetics and evolutionary biology.

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